Sergejs Berdnikovs, PhD

Research Project:
How Abnormal Metabolic Regulation in Airway Epithelial Cells Affect Body’s Response to Viral Infections

Grant Awarded:

Emerging Respiratory Pathogen Award

Research Topics:

basic biologic mechanisms
risk factors

Research Diseases:

COVID-19
respiratory viruses

People with type 2 diabetes, type 1 diabetes, obesity and metabolic syndrome are at a significantly higher risk for severe viral infections, including serious complications from COVID-19 and respiratory syncytial virus (RSV). Metabolic diseases are also linked to “long COVID,” vaccine breakthrough infections and higher likelihood of co-infection with other viruses, such as RSV. Surprisingly, infection with COVID-19 worsens diabetes and insulin resistance, and significantly increases the risk of developing new diabetes. Despite clear associations between these metabolic conditions and severe viral infection, the mechanisms involved remain poorly understood. Our research will explore how metabolic dysregulation in airway epithelial cells (which are the initial point of contact for respiratory viruses) affects the body's response to viral infections. The findings will significantly advance our understanding of risk factors for coronavirus infection and will improve preparedness for future pandemics.

Page last updated: October 7, 2024

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