Tatsuya Tsukui, PhD

Research Project:
Determining Role of Inflammatory Signals on Fibroblasts in Pulmonary Fibrosis

Grant Awarded:

Hastings Innovation Award for Interstitial Lung Disease

Research Topics:

basic biologic mechanisms
immunology immunotherapy
pathology

Research Diseases:

interstitial lung disease
pulmonary fibrosis

In pulmonary fibrosis, ongoing lung injury leads to the replacement of healthy lung tissue with scarred fibrous tissue produced by diseased fibroblasts (cells that contribute to the formation of connective tissue). This impairs lung function. Currently, there is no treatment that can reverse pulmonary fibrosis. Inflammatory responses in lung tissue trigger a series of events that promote fibrosis following injury. We recently identified different types of fibroblasts that arise from specific inflammatory signals in pulmonary fibrosis. However, the impact of these diverse inflammatory signals on the behavior of diseased fibroblasts remains unclear. We will determine the role of these inflammatory signals on fibroblasts in pulmonary fibrosis by using innovative tools, which we recently generated to specifically target fibroblast subsets. These studies will show how inflammatory signals contribute to pulmonary fibrosis and may lead to novel therapeutic strategies to target inflammatory fibroblasts.

Page last updated: November 22, 2024

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