Donate
Call the Lung HelpLine
Ask a Question
The following text field filters the results that follow as you type. Use Tab to access the results.
  1. Home
  2. Research & Reports
  3. About Our Research
  4. Previously Funded Researchers
  5. Elnaz Atabakhsh, Ph.D.
Elnaz Atabakhsh, Ph.D.

Elnaz Atabakhsh, Ph.D.

Massachusetts General Hospital

Research Project:
Gene Mutation Makes Lung Cancer Less Responsive to Treatment

Grant Awarded:

  • Senior Research Training Fellowship

Research Topic:

  • gene expression transcription

Research Disease:

  • lung cancer

We are studying the function of a protein called KDM4A in non-small cell lung cancer (NSCLC). KDM4A helps regulate how genes are organized. We found when KDM4A is over-produced in cells there are specific alterations to the organism's DNA. These alterations result in selection of regions involved in cancer drug resistance. We have also identified a KDM4A gene variant that is associated with poor outcome in NSCLC patients. This variant also changes lung cancer cell sensitivity to certain drug treatments. We will study the impact of the genetic alterations caused by KDM4A overexpression and establish how KDM4A levels impact lung cancer cells' response to chemotherapy. Our research could identify new treatment options for NSCLC patients.

Page last updated: April 30, 2024

Living Well With COPD
, | Nov 20, 2024 Freedom From Smoking Clinic
Manchester, CT | Jan 06, 2025
See All Events